Unconventional use of LC3 by coronaviruses through the alleged subversion of the ERAD tuning pathway.
Identifieur interne : 002016 ( Main/Exploration ); précédent : 002015; suivant : 002017Unconventional use of LC3 by coronaviruses through the alleged subversion of the ERAD tuning pathway.
Auteurs : Fulvio Reggiori [Pays-Bas] ; Cornelis A M. De Haan ; Maurizio MolinariSource :
- Viruses [ 1999-4915 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Autophagie (physiologie), Coronaviridae (physiologie), Dégradation associée au réticulum endoplasmique, Humains, Infections à Coronaviridae (virologie), Mammifères (métabolisme), Modèles biologiques, Protéines associées aux microtubules (métabolisme), Protéines membranaires (métabolisme), Réplication virale, Réticulum endoplasmique (métabolisme), Réticulum endoplasmique (virologie), Souris, Vésicules de transport (métabolisme), Vésicules de transport (virologie).
- MESH :
- métabolisme : Mammifères, Protéines associées aux microtubules, Protéines membranaires, Réticulum endoplasmique, Vésicules de transport.
- physiologie : Autophagie, Coronaviridae.
- virologie : Infections à Coronaviridae, Réticulum endoplasmique, Vésicules de transport.
- Animaux, Dégradation associée au réticulum endoplasmique, Humains, Modèles biologiques, Réplication virale, Souris.
English descriptors
- KwdEn :
- Animals, Autophagy (physiology), Coronaviridae (physiology), Coronaviridae Infections (virology), Endoplasmic Reticulum (metabolism), Endoplasmic Reticulum (virology), Endoplasmic Reticulum-Associated Degradation, Humans, Mammals (metabolism), Membrane Proteins (metabolism), Mice, Microtubule-Associated Proteins (metabolism), Models, Biological, Transport Vesicles (metabolism), Transport Vesicles (virology), Virus Replication.
- MESH :
- chemical , metabolism : Membrane Proteins, Microtubule-Associated Proteins.
- metabolism : Endoplasmic Reticulum, Mammals, Transport Vesicles.
- physiology : Autophagy, Coronaviridae.
- virology : Coronaviridae Infections, Endoplasmic Reticulum, Transport Vesicles.
- Animals, Endoplasmic Reticulum-Associated Degradation, Humans, Mice, Models, Biological, Virus Replication.
Abstract
Pathogens of bacterial and viral origin hijack pathways operating in eukaryotic cells in many ways in order to gain access into the host, to establish themselves and to eventually produce their progeny. The detailed molecular characterization of the subversion mechanisms devised by pathogens to infect host cells is crucial to generate targets for therapeutic intervention. Here we review recent data indicating that coronaviruses probably co-opt membranous carriers derived from the endoplasmic reticulum, which contain proteins that regulate disposal of misfolded polypeptides, for their replication. In addition, we also present models describing potential mechanisms that coronaviruses could employ for this hijacking.
DOI: 10.3390/v3091610
PubMed: 21994798
Affiliations:
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Le document en format XML
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F.Reggiori@umcutrecht.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht</wicri:regionArea><wicri:noRegion>3584 CX Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="De Haan, Cornelis A M" sort="De Haan, Cornelis A M" uniqKey="De Haan C" first="Cornelis A M" last="De Haan">Cornelis A M. De Haan</name></author><author><name sortKey="Molinari, Maurizio" sort="Molinari, Maurizio" uniqKey="Molinari M" first="Maurizio" last="Molinari">Maurizio Molinari</name></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Autophagy (physiology)</term><term>Coronaviridae (physiology)</term><term>Coronaviridae Infections (virology)</term><term>Endoplasmic Reticulum (metabolism)</term><term>Endoplasmic Reticulum (virology)</term><term>Endoplasmic Reticulum-Associated Degradation</term><term>Humans</term><term>Mammals (metabolism)</term><term>Membrane Proteins (metabolism)</term><term>Mice</term><term>Microtubule-Associated Proteins (metabolism)</term><term>Models, Biological</term><term>Transport Vesicles (metabolism)</term><term>Transport Vesicles (virology)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Autophagie (physiologie)</term><term>Coronaviridae (physiologie)</term><term>Dégradation associée au réticulum endoplasmique</term><term>Humains</term><term>Infections à Coronaviridae (virologie)</term><term>Mammifères (métabolisme)</term><term>Modèles biologiques</term><term>Protéines associées aux microtubules (métabolisme)</term><term>Protéines membranaires (métabolisme)</term><term>Réplication virale</term><term>Réticulum endoplasmique (métabolisme)</term><term>Réticulum endoplasmique (virologie)</term><term>Souris</term><term>Vésicules de transport (métabolisme)</term><term>Vésicules de transport (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Membrane Proteins</term><term>Microtubule-Associated Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endoplasmic Reticulum</term><term>Mammals</term><term>Transport Vesicles</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Mammifères</term><term>Protéines associées aux microtubules</term><term>Protéines membranaires</term><term>Réticulum endoplasmique</term><term>Vésicules de transport</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Autophagie</term><term>Coronaviridae</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Autophagy</term><term>Coronaviridae</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à Coronaviridae</term><term>Réticulum endoplasmique</term><term>Vésicules de transport</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronaviridae Infections</term><term>Endoplasmic Reticulum</term><term>Transport Vesicles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Endoplasmic Reticulum-Associated Degradation</term><term>Humans</term><term>Mice</term><term>Models, Biological</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Dégradation associée au réticulum endoplasmique</term><term>Humains</term><term>Modèles biologiques</term><term>Réplication virale</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pathogens of bacterial and viral origin hijack pathways operating in eukaryotic cells in many ways in order to gain access into the host, to establish themselves and to eventually produce their progeny. The detailed molecular characterization of the subversion mechanisms devised by pathogens to infect host cells is crucial to generate targets for therapeutic intervention. Here we review recent data indicating that coronaviruses probably co-opt membranous carriers derived from the endoplasmic reticulum, which contain proteins that regulate disposal of misfolded polypeptides, for their replication. In addition, we also present models describing potential mechanisms that coronaviruses could employ for this hijacking.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="De Haan, Cornelis A M" sort="De Haan, Cornelis A M" uniqKey="De Haan C" first="Cornelis A M" last="De Haan">Cornelis A M. De Haan</name><name sortKey="Molinari, Maurizio" sort="Molinari, Maurizio" uniqKey="Molinari M" first="Maurizio" last="Molinari">Maurizio Molinari</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Reggiori, Fulvio" sort="Reggiori, Fulvio" uniqKey="Reggiori F" first="Fulvio" last="Reggiori">Fulvio Reggiori</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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